Xinyu Guo

I'm a rising research assistant at the Hong Kong Polytechnic University, supervised by Daniel T.L. Shek. Previously, I got my master's degree in Sichuan University.

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Xinyu Guo

Research

I am interested in using computational, statistical, and data-driven methods to understand public and mental health, and to develop interpretable predictive models from electronic health records (EHR).

NSSI Research
Longitudinal machine learning prediction of non-suicidal self-injury among Chinese adolescents: A prospective multicenter cohort study
Xinyu Guo, Liu, S., Jiang, L., Xiong, Z., Wang, L., Lu, L., ... & Daniel T.L. Shek
Journal of Affective Disorders, 2025, 120110. [Q1, IF: 4.9]
code / paper

We introduce a progressive prediction framework utilizing four waves of longitudinal data and seven machine learning algorithms to predict NSSI risk among 3,483 Chinese adolescents.

Causal Analysis Research
Factors and pathways of non-suicidal self-injury in children: Insights from computational causal analysis
Xinyu Guo, Wang, L., Li, Z., Feng, Z., Lu, L., Jiang, L., & Zhao, L.
Frontiers in Public Health, 2024, 12, 1305746. [Q1, IF: 3.4]
project / paper

Utilizing computational causal analysis to identify key factors and pathways contributing to non-suicidal self-injury behaviors in children, providing insights for intervention strategies.

CRISP Framework
CRISP: A causal relationships-guided deep learning framework for advanced ICU mortality prediction
Wang, L., Xinyu Guo, Shi, H., Ma, Y., Bao, H., Jiang, L., Zhao, L., Feng, Z., Zhu, T., & Lu, L.
BMC Medical Informatics and Decision Making, 2025, 25(1), 165. [Q2, IF: 3.8]
code / paper

A novel deep learning framework that leverages causal relationships to improve mortality prediction in intensive care units, demonstrating superior performance over traditional approaches.

COVID-19 Study
Life changes and symptoms of depression and anxiety among Chinese children and adolescents before, during, and after the COVID-19 pandemic lockdown: a combination of cross-sectional, longitudinal, and clustering studies
Zeng, Y., Song, J., Zhang, Y., Xinyu Guo, Xu, X., Fan, L., Zhao, L., Song, H., & Jiang, L.
European Child & Adolescent Psychiatry, 2025, 34(3), 1025-1038. [Q1, IF: 4.9]
project / paper

A comprehensive analysis of mental health changes in Chinese youth during the COVID-19 pandemic, combining multiple study designs to understand the impact of lockdown measures on depression and anxiety symptoms.

Cognitive Impairment Research
Dynamic causal graph-based learning approach for predicting cognitive impairment in middle-aged and older adults
Wang, L., Xinyu Guo, Zhou, Y., Li, Z., Jiang, L., Zhao, L., Feng, Z., & Lu, L.
In Proceedings of the 46th Annual Conference of the Cognitive Science Society, 2024, Vol. 46. [Conference]
paper

A dynamic causal graph-based machine learning approach for predicting cognitive impairment in aging populations, incorporating temporal relationships and causal mechanisms for improved accuracy.

Granger Causality Study
Prediction of cognitive impairment in middle-aged and elderly people: A method based on Granger causality
Li, S., Wang, L., Xinyu Guo, Shi, H., Ma, Y., Zhang, X., Feng, Z., & Lu, L.
In Proceedings of the 47th Annual Conference of the Cognitive Science Society, 2025, Vol. 47. [Conference]
paper

A novel approach utilizing Granger causality methods for predicting cognitive impairment in middle-aged and elderly populations, focusing on temporal causal relationships in cognitive decline.

MDRO Study
Causality-driven models for MDRO infection prediction: Enabling effective ICU antibiotic stewardship
Wang, L., Xinyu Guo(co-first author), Jiang, L., Li, Z., Zhao, L., Feng, Z., & Lu, L.
2025. (Under review)

Development of causality-driven predictive models for multidrug-resistant organism (MDRO) infections in ICU settings, aimed at improving antibiotic stewardship programs and reducing healthcare-associated infections.

Academic Values Study
Academic values, academic anxiety, and non-suicidal self-injury in Chinese adolescents: A three-wave longitudinal study
Xinyu Guo, Peng, Y., Li, X., Zhao, L., Jiang, L., & Shek, D. T. L.
BMC Psychology, 2025. (Under review)

A longitudinal investigation examining the relationships between academic values, academic anxiety, and non-suicidal self-injury behaviors among Chinese adolescents across three time points.

Project

Several projects that I lead are listed below:

NSSI Research
Chengdu Positive Child Development (CPCD) Survey
Project Description

I directed the 5th wave of the survey, including coordination with participating schools and logistical planning and managed field surveys, data entry using Epidata, and ensured accuracy in preliminary data processing.

I independently conducted data matching, screening, cleaning, and missing value imputation for Waves 1-4, then developed a longitudinal machine learning model to predict adolescent NSSI, published in Journal of Affective Disorders, 2025.

Chinese General Social Survey (CGSS)
Chinese General Social Survey (CGSS)
Project Description

I co-led the 2023 Sichuan Province survey team, with responsibilities including project planning and coordination, field household interviews, and software management.

Chronic Disease and Health Literacy Survey
Chronic Disease and Health Literacy Survey

I led a chronic disease and health literacy survey across 7 Sichuan Province cities, organizing field data collection and interviews, analyzing and visualizing results, and preparing the research report for government departments.


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